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ESIS in Pediatric DRE

NCT05469373 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 86

Last updated 2025-12-23

No results posted yet for this study

Summary

The main reason for this research study is to gain information about how the brain makes seizures by causing seizures using very small amounts of current, or electrical stimulation. Using small amounts of current to cause seizures (or stimulate) is not new at CCHMC - it is part of routine clinical practice for some patients at some electrodes.

This study differs from routine clinical care in that all study patients will undergo electrical stimulation in all or nearly all electrode contacts. The study team is doing this because there is promising data in adult patients that stimulating comprehensively (targeting all or nearly all of the electrode contacts) helps define the seizure network. Defining the seizure network in turn helps the medical team plan surgery. So far, there is not as much published data on seizure stimulation for pediatric patients.

This research study thus has the potential both to help individual patients (by providing specific information about your seizure networks) and to help pediatric patients with epilepsy in general (by increasing our understanding of stimulated seizures in children, teenagers and young adults).

Conditions

Sponsors & Collaborators

  • Network for Excellence in Neuroscience Clinical Trials

    collaborator UNKNOWN

  • Child Neurologist Career Development Program

    collaborator UNKNOWN

  • Sarah Katie Ihnen

    lead OTHER

Principal Investigators

  • Sarah Katie Ihnen, MD, PhD · Children's Hospital Medical Center, Cincinnati

Eligibility

Min Age
1 Year
Max Age
30 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-02-17
Primary Completion
2026-06-30
Completion
2027-12-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05469373 on ClinicalTrials.gov