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Ictal SPECT With Intra-arterial Injection

NCT02513992 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2020-09-18

No results posted yet for this study

Summary

Ictal SPECT with intravenous injection in a cubital vein of a perfusion tracer is an established technique to localize the ictal onset zone during presurgical evaluation of refractory focal epilepsy. When seizures last less than 10 seconds, localizing information is often not obtained. Since it takes around 30 seconds before the tracer reaches the brain after intravenous injection, ictal hyperperfusion most likely has already switched to postictal hypoperfusion. In this study, we plan to inject the perfusion tracer in the aorta proximal to the cerebral arteries, which will allow a true ictal injection in patients with seizures of short duration.

Conditions

Interventions

PROCEDURE

intra-arterial injection of tracer

intra-arterial ictal injection of perfusion tracer

DRUG

99m-Technetium Ethyl Cysteinate Dimer

administration of perfusion tracer 99m Tc-ECD during epileptic seizure

DEVICE

intra-arterial catheter

placement of intra-arterial catheter via femoral artery

DEVICE

pressure injector

the injection of the perfusion tracer will be delivered with a pressure injector

Sponsors & Collaborators

  • Universitaire Ziekenhuizen KU Leuven

    lead OTHER

Principal Investigators

  • Wim Van Paesschen, MD PhD · UZ Leuven/KU Leuven

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-05-31
Primary Completion
2018-07-31
Completion
2018-07-31

Countries

  • Belgium

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02513992 on ClinicalTrials.gov