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Effect of Estrogen Treatment on Drug Metabolism and Transport

NCT05469204 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2026-01-09

No results posted yet for this study

Summary

This project will evaluate the effect of estrogen treatment on how other medications are processed by the body.

Conditions

  • Transgender Persons

Interventions

DRUG

Midazolam oral solution

2 mg single-dose before and during estradiol treatment.

DRUG

Digoxin Oral Tablet

0.25 mg single-dose before and during estradiol treatment.

DRUG

Acetaminophen Oral Tablet

500 mg single-dose before and during estradiol treatment.

DRUG

Midazolam Injectable Solution

1 mg intravenous single-dose before and during estradiol treatment.

Sponsors & Collaborators

Study Design

Allocation
NA
Purpose
OTHER
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-11-01
Primary Completion
2025-07-30
Completion
2025-07-30
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05469204 on ClinicalTrials.gov