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Impact of Nocturnal Hypoxemia on Glucose in High Altitude Sleep Disordered Breathing

NCT05462834 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2026-01-07

No results posted yet for this study

Summary

Sleep disordered breathing is associated with impaired glucose tolerance and incident diabetes. Nocturnal hypoxemia is a potential stimulus of glucose intolerance. It is especially severe and highly prevalent in high altitude residents. Intervening on nocturnal hypoxemia may therefore improve glucose control and decrease the public health burden in high altitude populations.

The objective of this study is to examine the impact of hypoxemia on glucose homeostasis in high altitude residents. The investigators will address this objective by examining the effect of supplemental oxygen on glucose in a randomized cross-over study.

Conditions

  • Sleep-Disordered Breathing
  • Glucose Intolerance

Interventions

OTHER

Compressed Air

Participants will be instructed to use compressed air during sleep as a placebo control.

OTHER

Supplemental Oxygen

Participants will be instructed to use supplemental oxygen at rate of 2lpm during sleep.

Sponsors & Collaborators

  • National Institutes of Health (NIH)

    collaborator NIH

  • PRISMA A.B.

    collaborator UNKNOWN

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • Johns Hopkins University

    lead OTHER

Principal Investigators

  • Luu Pham, MD · Johns Hopkins University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-12-01
Primary Completion
2025-12-01
Completion
2025-12-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05462834 on ClinicalTrials.gov