MedTrace Logo

BioFINDER-Brown: Examination of Alzheimer's Disease Biomarkers

NCT05457998 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2024-12-17

No results posted yet for this study

Summary

This research study aims to examine biomarkers of Alzheimer's disease as early as possible which could potentially be a screening tool for the general population. This observational study will take place at the Memory and Aging Program at Butler Hospital. The study will enroll up to 200 cognitively healthy subjects aged 50 to 80 years with ongoing recruitment and enrollment for 2 years, and subject participation lasting approximately 4 years. Disclosure of AD risk assessments will be an optional procedure. Two PET imaging sub-studies will also be optional.

Conditions

Interventions

DIAGNOSTIC_TEST

Flutemetamol F18 Injection

PET imaging of Abeta amyloid

DIAGNOSTIC_TEST

[18F]-RO6958948 Injection

PET imaging of Tau aggregates

DIAGNOSTIC_TEST

[18F]-MK-6240 Injection

PET imaging of Tau aggregates

Sponsors & Collaborators

  • The Warren Alpert Foundation

    collaborator UNKNOWN

  • Brown University

    collaborator OTHER

  • University of Rhode Island

    collaborator OTHER

  • Hoffmann-La Roche

    collaborator INDUSTRY

  • Eli Lilly and Company

    collaborator INDUSTRY

  • GE Healthcare

    collaborator INDUSTRY

  • Butler Hospital

    lead OTHER

Principal Investigators

  • Edward Huey, MD · Butler Hospital Memory and Aging Program

Eligibility

Min Age
50 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-06-14
Primary Completion
2028-06-30
Completion
2028-06-30
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05457998 on ClinicalTrials.gov