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Free-Base Nicotine or Nicotine Salt e-Liquids in Current E-Cigarette Smokers, PeloPET Study

NCT05455086 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 21

Last updated 2025-03-24

Study results available
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Summary

This clinical trial studies the effect of free-base compared with nicotine salt based e-liquids on electronic cigarette (EC) puffing behavior, abuse liability, and deposition and absorption of nicotine in the respiratory tract and rate of uptake in the brain in current EC smokers. The results from this study may provide much needed scientific information to public health officials and regulators.

Conditions

  • Cigarette Smoking-Related Carcinoma

Interventions

BEHAVIORAL

Cigarette Smoking

Receive 1 puff of tobacco flavored protonated e-liquid

BEHAVIORAL

Cigarette Smoking

Receive 1 puff of unflavored protonated e-liquid

BEHAVIORAL

Cigarette Smoking

Receive 1 puff of tobacco flavored unprotonated cigarette

BEHAVIORAL

Cigarette Smoking

Receive 1 puff of unfavored unprotonated cigarette

PROCEDURE

Computed Tomography

Undergo PET/CT

PROCEDURE

Positron Emission Tomography

Undergo PET/CT

OTHER

Questionnaire Administration

Ancillary studies

Sponsors & Collaborators

  • Ohio State University Comprehensive Cancer Center

    lead OTHER

Principal Investigators

  • Theodore L Wagener, PhD · Ohio State University Comprehensive Cancer Center

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-03-23
Primary Completion
2023-06-26
Completion
2023-06-26

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05455086 on ClinicalTrials.gov