Emptying Malaria Reservoirs to Accelerate Malaria Elimination in High Transmission Settings

Summary

The study is a Phase 2 randomized controlled, partial-blind, parallel group study in plasmodium infected asymptomatic adults 18 years and older, with 8 study arms. It will use the adapted Zelen design, which has two steps in the consent process. In the first step, there is an informed consent from all participants for a cohort lifestyle study. According to this consent, participants are randomized without knowledge about the detailed protocol.

In the second step, only participants from the intervention group will receive the information about the intervention and the second consent will be obtained from them. The participants who will decline to participate to an intervention will continue in the cohort study, as the control group.

Conditions

• Asymptomatic Malaria

Interventions

OTHER

Artemisia afra tea infusions

A. afra infusions of 5g/1litter of water, 3drinks a day, daily for 1week (7 days) (current recommendation).

OTHER

Artemisia afra tea infusions

A. afra infusions of 5g/500ml of water, 2drinks a day, daily for 1week (7 days) (increase concentration and decrease dose frequency).

OTHER

Artemisia afra tea infusions

A. afra infusions,5g/1liter of water, 3drinkss a day, weekly for 4weeks (decrease dose frequency and increase length of treatment).

OTHER

Artemisia afra tea infusions

A. afra infusions, 5g/1liter of water, 3drinks a day, daily for1week (7 days) (current treatment with improved taste).

OTHER

Artemisia afra tea infusions

A. afra infusions, 5g/500ml of water, 2drinks a day, daily for 1 week (7 days) (improved taste, increase concentration and decrease dose frequency).

OTHER

Artemisia afra tea infusions

Group of 8 persons receiving flavored A. afra infusions, 5g/1liter of water, 3drinks a day, weekly for 4weeks (improved taste, decrease dose frequency and increase length of treatment).

OTHER

Flavored placebo infusions

Flavored placebo infusions, 5g/liter of water, 3drinks a day, daily for 1week (7 days) (improved taste with no active molecule)

OTHER

Regular tea placebo

Regular tea placebo taken as desired, daily for 1 week (7 days) (Regular tea with no active molecule).

Sponsors & Collaborators

• Université Catholique de Louvain

  lead OTHER

Principal Investigators

• Suh Nchang Abenwie, MSc. MPH · UCLouvain, Bruxells -Belgium

• Robert Annie, Professor · Université Catholique de Louvain

• Souopgui Jacob, Professor · Université Libre de Bruxelles

• Ghogomu Stephen, Professor · University of Buea, Cameroon

• Frederick Michel, Professor · Université de Liège

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-04-30

Primary Completion

2023-06-30

Completion

2024-02-29