Re-optimization Based Online Adaptive Radiotherapy of Anal Cancer
NCT05438836 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 205
Last updated 2023-09-25
Summary
A single-arm, prospective, Phase II, single-center clinical trial that will investigate if daily online adaptive radiotherapy for anal cancer will significantly reduce early treatment-related GI toxicity compared with the historically reported rate for non-adaptive intensity modulated radiation therapy (IMRT).
Conditions
- Anal Cancer
- Anal Carcinoma
- Anal Squamous Cell Carcinoma
Interventions
- RADIATION
-
online adaptive radiotherapy
Online adaptive radiotherapy compared to standard non-adaptive Image-Guided Radiotherapy
Sponsors & Collaborators
-
Herlev Hospital
lead OTHER
Principal Investigators
-
Eva S Serup-Hansen, MD, PhD · Herlev og Gentofte Hospital
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-01-01
- Primary Completion
- 2026-01-01
- Completion
- 2031-01-01
Countries
- Denmark
Study Locations
More Related Trials
-
Neoadjuvant Short-course Radiotherapy Followed by the Combination of Immunotherapy and Chemotherapy in Locally Advanced Rectal Cancer
NCT04663763 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Hypofractionated Radiotherapy Combined With NALIRIF, PD-1 Antibody in Locally Recurrent Rectal Cancer(NOVELTY-R)
NCT07183865 ·Status: RECRUITING ·Phase: PHASE2
-
Intraoperative Electron Radiotherapy in Rectal Cancer - A Feasibility Trial
NCT05877352 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Immunotherapy In Locally Advanced Rectal Cancer
NCT03854799 ·Status: COMPLETED ·Phase: PHASE2
-
Comparison of Preoperative and Postoperative Radiotherapy and Capecitabine in Locally Advanced Rectal Cancer
NCT01186081 ·Status: COMPLETED ·Phase: PHASE3
-
Talimogene Laherparepvec, Chemotherapy, and Radiation Therapy Before Surgery in Treating Patients With Locally Advanced or Metastatic Rectal Cancer
NCT03300544 ·Status: TERMINATED ·Phase: PHASE1
-
Circulating Biomarkers in Patients With Anal Cancer Treated With Induction Chemotherapy
NCT05233540 ·Status: RECRUITING
-
MR-Adaptive Radiation Therapy for Anal Cancer With EScalated-Treatment in a Risk-Optimized Approach
NCT06050707 ·Status: RECRUITING ·Phase: PHASE2
-
ADAR1 Expression Level in Rectal Cancer
NCT07108348 ·Status: RECRUITING
-
A Study of Total Neoadjuvant Therapy for High-risk Locally Advanced Rectal Cancer
NCT04543695 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
NCT07292298 ·Status: RECRUITING ·Phase: PHASE2
-
Preoperative Radiotherapy and E7046 in Rectum Cancer
NCT03152370 ·Status: COMPLETED ·Phase: PHASE1
-
Organ Preservation Following Enverolimab-based Total Neoadjuvant Therapy for Locally Advanced Very Low Rectal Cancer
NCT05969847 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Neoadjuvant Treatment for Advanced Rectal Carcinoma
NCT02551237 ·Status: COMPLETED ·Phase: PHASE3
-
Hypofractionated Radiotherapy Plus Immunotherapy Versus Conventional Radiotherapy in Locally Recurrent Rectal Cancer
NCT06928584 ·Status: RECRUITING ·Phase: PHASE2
-
Radiotherapy Plus Iparomlimab and Tuvonralimab (QL1706), Regorafenib, and CAPOX as Neoadjuvant Therapy for pMMR/MSS LARC.
NCT06911684 ·Status: RECRUITING ·Phase: PHASE2
-
Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma
NCT05752136 ·Status: RECRUITING ·Phase: PHASE3
-
Chemo-radiotherapy as Main Treatment Strategy for Rectal Cancer. Can we Provide a More Precise and Effective Treatment
NCT03619668 ·Status: UNKNOWN
-
Resource-Sparing Curative Treatment for Rectal Cancer
NCT01459328 ·Status: UNKNOWN ·Phase: PHASE3
-
Study on the Efficacy and Safety of Neoadjuvant Radiotherapy Combined With Toripalimab, Liposomal Irinotecan, and Capecitabine in the Treatment of pMMR Locally Advanced Rectal Adenocarcinoma With Low Rectal Involvement
NCT07104604 ·Status: RECRUITING ·Phase: PHASE1
-
"Oncologic Results and Risk Factors for Recurrence in Patients With Locally Advanced Rectal Cancer and Pathologic Complete Response After Neoadjuvant Treatment. Results From an Observational Retrospective Multicenter Long-term Follow-up Study".
NCT05495308 ·Status: COMPLETED
-
Total Neoadjuvant Treatment Combined With Adaptive Radiotherapy for Rectal Cancer
NCT05883800 ·Status: RECRUITING ·Phase: NA
-
QOL & Functional Outcomes After Combined Modality Tx for Anal CA: Comparison of Conventional vs IMRT
NCT00568425 ·Status: TERMINATED
-
TNT of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer
NCT05646511 ·Status: RECRUITING ·Phase: PHASE3
-
Study to Nivolumab Following Preoperative Chemoradiotherapy
NCT02948348 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2