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Prediction of Chemotherapy Toxicity and Survival in Elderly Cancer Patients by CARG Score

NCT05432726 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 63

Last updated 2022-07-19

No results posted yet for this study

Summary

Prediction of chemotherapy toxicity and survival in elderly (aged ≥65 years old) patients with advanced solid tumors receiving systemic chemotherapy by using CARG risk score.

Conditions

  • Solid Tumors ,Adults

Interventions

OTHER

calculating CARG score

Before the initiation of chemotherapy, study participants will complete the GA questions included in the CARG toxicity score. Total risk score will be calculated ranging from 0 (lowest toxicity risk) to 19 (highest toxicity risk), incorporates measures of functional status such as fall history, hearing problems, physical capabilities, performance status as well as objective measures including age, gender, height, weight, cancer type, type and dose of chemotherapy, hemoglobin, and creatinine clearance. CARG score will be stratified as low (score 0-5), intermediate (score 6-9) and high risk (score 10-19). Chemotherapy-related toxicities will be assessed and graded as per the NCI-CTCAE, version 5.0. Hospitalizations due to AEs during first-line chemotherapy will be collected. Subsequent changes in chemotherapy dosage, treatment delays, and treatment discontinuation due to adverse effects as well as mortality rate after treatment will also be monitored.

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-07-20
Primary Completion
2025-07-01
Completion
2025-07-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05432726 on ClinicalTrials.gov