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Effect of stRess and exeRcize on the Outcome After Chemo-Radiation

NCT05431348 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 42

Last updated 2026-03-04

No results posted yet for this study

Summary

Glioblastoma (GBM) is a highly malignant, incurable primary brain tumor. Due to the nature of this disease and the extent of the treatment (surgery followed by chemoradiation according to the Stupp trial) patients undergo considerable psychological distress. It is known that stress hormones are involved in a wide range of processes involved in cell survival, cell cycle and immune function, and can cause therapy resistance. In this study the effect of stress on outcome after chemoradiation in patients with GBM will be investigated.

Conditions

  • Glioblastoma (GBM)

Interventions

DEVICE

Smartwatch

Patients will wear the smartwatch during treatment which measures, activity, steps, sleep and heartrate

DIAGNOSTIC_TEST

Serum Cortisol

Level of cortisol in serum will be determined

OTHER

Questionnaires

Patients are asked to fill in patient reported outcomes (PROMS) and specific questions on stress, exercise and fatigue (QSC-R23, IPAQ-SF, MVI-20)

Sponsors & Collaborators

  • Maastricht University Medical Center

    collaborator OTHER

  • Zuyderland Medical Centre

    collaborator OTHER

  • Verbeeten Institute Tilburg

    collaborator UNKNOWN

  • Maastricht Radiation Oncology

    lead OTHER

Principal Investigators

  • Karen Zegers, PhD · Maastro Clinic, The Netherlands

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-06-01
Primary Completion
2026-03-01
Completion
2026-03-01

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05431348 on ClinicalTrials.gov