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Cannabis, HIV and Mental Processing Systems

NCT05430490 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 276

Last updated 2026-04-07

No results posted yet for this study

Summary

This study employs novel methods to identify key determinants and consequences of concurrent HIV infection and regular cannabis use. This study will acquire extensive phenotype data from peripheral and brain markers of immune activation, brain structure, and neuropsychological performance (NP) in persons living with HIV (PLWH) receiving combination anti-retroviral therapy (cART) (80 regular cannabis users and 80 non-users) and HIV uninfected (HIV-) controls (80 regular cannabis users and 80 non-users). This study will provide key insights into the effects of regular cannabis and HIV on peripheral and brain markers of immune function and NP in PLWH and HIV- controls. These insights are critical for cure strategies and ongoing HIV treatment initiatives.

Conditions

  • HIV Infections
  • Cannabis

Interventions

PROCEDURE

MRI

Multimodal neuroimaging on 3T Prisma Fit MRI

OTHER

NeuroPsychological Testing

A series of written, verbal, and motor tasks requiring the participant to follow instructions, remember words and numbers, draw objects, and complete timed actions.

PROCEDURE

Blood Draw

Laboratory reports (CMP, CBC, Lipids)

OTHER

Questionnaires

Life history, current behaviors, and substance use surveys

PROCEDURE

Lumbar Puncture

Optional procedure which involves obtaining cerebral spinal fluid through a needle in the lower back

Sponsors & Collaborators

  • Rutgers University

    collaborator OTHER

  • Washington University School of Medicine

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-03-23
Primary Completion
2026-03-01
Completion
2026-03-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05430490 on ClinicalTrials.gov