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Brain Imaging for HIV-Associated Thinking and Mood Disorders

NCT01692236 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 84

Last updated 2019-12-05

No results posted yet for this study

Summary

Background:

\- Human immunodeficiency virus (HIV) infection appears to cause problems with blood vessel function. These problems may add to some thinking and mood disorders found in people with HIV infection. Researchers want to evaluate HIV infected patients to see if blood vessel function contributes to thinking and mood disorders, such as early dementia and depression. To do so, they will compare study results between people with and people without HIV infection.

Objectives:

* To compare the thickness of blood vessel walls between people with and without HIV infection.
* To study the relationship between blood vessel thickness and thinking and mood disorders.

Eligibility:

* Individuals between 25 and 55 years of age who have HIV infection.
* Healthy individuals between 25 and 55 years of age.

Design:

* Participants will be screened with a physical exam and medical history. Blood and urine samples will be collected.
* Participants will have imaging studies of the brain and major blood vessels in the head and neck.
* Participants will also have neuropsychological testing. These tests will look at memory, learning and thinking ability, attention, and mood.
* Participants will have the option of coming back for repeat blood tests every six months and repeat imaging studies and neuropsychological tests every year, over 1- 4 years period.

Conditions

  • Human Immunodeficiency Virus
  • Neurocognitive Impairment

Sponsors & Collaborators

  • National Institute of Allergy and Infectious Diseases (NIAID)

    collaborator NIH

  • National Institutes of Health Clinical Center (CC)

    lead NIH

Principal Investigators

  • Avindra Nath, M.D. · National Institute of Neurological Disorders and Stroke (NINDS)

Eligibility

Min Age
25 Years
Max Age
61 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-09-13
Completion
2018-04-04

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01692236 on ClinicalTrials.gov