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Characterizing In Vivo Oral Lesion Impedances

NCT05430477 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 114

Last updated 2025-09-22

No results posted yet for this study

Summary

The primary objective of this study is to demonstrate a significant difference in electrical impedance between normal, benign, premalignant, and malignant oral lesions using a custom device. The secondary study objective is to create a database of in vivo electrical impedance spectra and images of oral lesions. This will be achieved by collecting Electrical Impedance sensing data and images from two cohorts of patients: Cohort I will consist of 200 patients undergoing oral lesion biopsies and Cohort II will be comprised of 50 patients scheduled for oral cancer resection. A maximum of 5 additional subjects will be initially enrolled in each Cohort to optimize data acquisition.

Conditions

  • Oral Lesion

Interventions

DEVICE

Electrical impedance imaging using Non-Significant Risk device (EII probe)

novel small field-of-view Non-Significant Risk device (EII probe)

Sponsors & Collaborators

  • National Institutes of Health (NIH)

    collaborator NIH

  • National Institute of Dental and Craniofacial Research (NIDCR)

    collaborator NIH

  • Dartmouth College

    collaborator OTHER

  • Ryan J. Halter

    lead OTHER

Principal Investigators

  • Ryan Halter, PhD · Trustees of Dartmouth College

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-08-29
Primary Completion
2025-06-30
Completion
2025-08-20

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05430477 on ClinicalTrials.gov