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A Study Comparing Perioperative Stress Reduction vs. Standard of Care in Ovarian Cancer (PRESERVE)

NCT05429970 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 35

Last updated 2026-05-18

No results posted yet for this study

Summary

The purpose of this study is to see if propranolol and etodolac along with mind-body resilience training/MBRT and music therapy help participants who are experiencing physiological stress before, during, and after primary debulking surgery/PDS or IDS and also if it's better than the standard-of-care approach (no intervention for reducing stress).

Conditions

  • Ovarian Cancer
  • Ovarian Carcinoma
  • Stage II Ovary Cancer
  • Stage II Ovarian Cancer
  • Stage III Ovary Cancer
  • Stage III Ovarian Cancer
  • Stage IV Ovary Cancer
  • Stage IV Ovarian Cancer
  • Epithelial Ovarian Cancer
  • Fallopian Tube Cancer
  • Stage II Fallopian Tube Cancer
  • Stage III Fallopian Tube Cancer
  • Stage IV Fallopian Tube Cancer
  • Primary Peritoneal Carcinoma

Interventions

BEHAVIORAL

Mind-body resilience training

MBRT is a meditation technique used to achieve relaxation)

BEHAVIORAL

Music therapy

Music listening was found, in multiple trials, to significantly reduce self-reported anxiety, physiologic indicators of anxiety, and/or sedation requirements

DRUG

Propranolol

Propranolol 20 mg PO BID (for 21 consecutive days), Propranolol 10mg PO BID (for 3 consecutive days POD 14-16)

DRUG

Etodolac

Etodolac 400 mg PO BID (for 21 consecutive days)

Sponsors & Collaborators

Principal Investigators

  • Kara Long Roche, MD · Memorial Sloan Kettering Cancer Center

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-06-17
Primary Completion
2026-06-17
Completion
2026-06-17

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05429970 on ClinicalTrials.gov