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Comparing Conventional Grid Laser Photocoagulation and Subthreshold Micropulse Laser in Diabetic Macular Edema Using OCT Angiography

NCT05416099 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2022-06-13

No results posted yet for this study

Summary

The prevalence of diabetes mellitus has increased significantly in Hong Kong for the past decade \[1\]. Diabetic macular edema is one of the most common causes of vision loss in patients suffering from diabetes mellitus \[3\]. Before the introduction of anti-vascular endothelial growth factor agents, laser photocoagulation has been the mainstay treatment for patients with diabetic macular edema. There are two types of laser treatment modalities, namely focal laser, which can be applied either in a grid pattern over a region of macular edema or to selected microaneurysms, and subthreshold micropulse laser. Only one meta-analysis published in 2016 \[16\] had previously demonstrated superiority of micropulse laser over focal laser, while other studies showed no clinically significant differences between the two lasers. Nevertheless, micropulse laser had been proven to cause no structural changes to the retina and choroid, as opposed to focal laser.

Optical coherence tomography angiography (OCT-A) is a new, non-invasive imaging technique that allows a clear, depth-resolved visualization of the retinal and choroidal microvasculature in the macular region \[22\]. A recent case series study \[17\] has demonstrated early changes of retinal vasculature on OCT-A images after micropulse laser for diabetic macular edema. Another cross-sectional study \[18\] showed choriocapillaries alterations in some of the patients after receiving focal laser. We would like to compare the changes of different OCT-A parameters for patients receiving either type of laser, and hence evaluating their efficacy.

We propose to take OCT-A images for patients before laser, 1-, 3- and 6-months post-laser based on the results of a recent case series \[17\]. We will analyse the OCT-A images with MATLAB software and compare the changes in different parameters between both lasers.

Conditions

Interventions

PROCEDURE

laser

grid vs micropulse laser

Sponsors & Collaborators

  • Chinese University of Hong Kong

    lead OTHER

Principal Investigators

  • Gabriel HK Li, M.B. Ch.B · CUHK

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-06-01
Primary Completion
2022-12-01
Completion
2022-12-01

Countries

  • China

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05416099 on ClinicalTrials.gov