CKD-aP Among Adults on Dialysis in Switzerland

Summary

Chronic Kidney Disease Associated Pruritus (CKD-aP) represents a localized or a generalized skin itch, which is a common symptom occurring in end-stage renal disease and dialysis. The prevalence of CKD-aP in adults on dialysis varies between countries ranging between 20-42%. Swiss data on CKD-aP are unfortunately largely lacking, as Switzerland is so far not part of large registries, such as DOPPS.

The aging population, the increase in diabetes (69% by 2030), the increase in hypertension (60% by 2025) and poly-morbidity will probably lead to a rise in the number of patients on dialysis and subsequent CKD-aP.

CKD-aP is associated with sleep disturbances, compromised quality of life, emotional distress, and increased risks of hospitalization and death. Its management lacks approaches that are supported by strong evidence because its pathogenesis remains poorly understood and may be related to an increase in uremic toxins, skin inflammation. In this context, sweat composition deserves more attention.

Aim of the study The aim of the study is to determine the prevalence of CKD-aP in the population on dialysis, the association between CKD-aP and different electrolytes, and the potential role of the composition of sweat in CKD-aP.

Results will be used for building a CKD-aP symptom management program to improve the quality of care of patients on dialysis and will be incorporated in the nursing continuing education program.

Conditions

• Chronic Kidney Diseases
• Dialysis
• Chronic Kidney Diseases Associated Pruritus

Interventions

OTHER

CKD-aP

Identification of CKD-aP prevalence and severity among patients on dialysis.

Sponsors & Collaborators

• University of Lausanne Hospitals

  collaborator OTHER

• Hôpital Fribourgeois

  collaborator OTHER

• University Hospital, Geneva

  collaborator OTHER

• Valais Hospital

  collaborator UNKNOWN

• eHnv Hospital

  collaborator UNKNOWN

• Rennaz Hospital

  collaborator UNKNOWN

• Intercantonal Hospital of Broye

  collaborator UNKNOWN

• GHOL Nyon Hospital

  collaborator UNKNOWN

• Dialyse Riviera

  collaborator UNKNOWN

• Cecil Clinic Hirslanden Private Hospital Group

  collaborator UNKNOWN

• Vifor Pharma

  collaborator INDUSTRY

• Réseau Hospitalier Neuchâtelois

  collaborator OTHER

• University of Applied Sciences of Western Switzerland

  lead OTHER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-09-01

Primary Completion

2023-10-09

Completion

2023-10-09

Countries

• Switzerland

Study Locations