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Effect of CoQ10 on the Endocrine Function of Skeletal Muscle

NCT05412888 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2023-01-04

No results posted yet for this study

Summary

Recent studies have also shown that repeated episodes of ischemia, followed by reperfusion (IPC), can contribute to the development of adaptive changes not only in the area of the heart muscle, but also in the structure of the skeletal muscles.

In the project, several research questions will be evaluated e.g. what is the relationship between oxidative stress parameters, uric acid concentration and nitric oxide degradation products in groups of people undergoing two-week training in ischemic training, or what is the relationship between the expression of genes associated with muscle cell growth (e.g. myostatin gene) and the effect of ischemia preconditioning training etc.

Conditions

  • Ischemic Preconditioning
  • Coenzyme Q Deficiency
  • Exercise Training

Interventions

DIETARY_SUPPLEMENT

CoQ10 supplementation

Young men training endurance running will be supplemented with CoQ10

PROCEDURE

Ischemic preconditioning training

Young men training endurance running will undergo IPC training

DIETARY_SUPPLEMENT

IPC training combined with CoQ10 supplementation

Young men training endurance running will undergo IPC training combined with CoQ10 supplementation

DIETARY_SUPPLEMENT

Sham IPC combined with placebo

Young men training endurance running will undergo sham IPC training combined with placebo supplementation

Sponsors & Collaborators

  • Medical University of Gdansk

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Max Age
29 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-03-01
Primary Completion
2023-07-31
Completion
2026-09-30

Countries

  • Poland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05412888 on ClinicalTrials.gov