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Systemic Transthyretin Amyloidosis: Carpal Tunnel Syndrome in a Portuguese Population

NCT05409833 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2023-10-19

No results posted yet for this study

Summary

Systemic transthyretin amyloidosis is an aging-related disorder. It is usually associated with cardiac disease but also extends to other organs. Recent studies found that idiopathic carpal tunnel syndrome patients may have amyloid deposition in tenosynovial tissue. The main aims of this project are the characterization of the association between idiopathic carpal tunnel syndrome and transthyretin amyloidosis and its evaluation as a predictive factor of cardiac amyloidosis

Conditions

  • Transthyretin Amyloidosis
  • Carpal Tunnel Syndrome

Interventions

DIAGNOSTIC_TEST

Synovial biopsy and Cardiac scintigraphy with [99mTc]Tc-DPD

Congo red and Immunohistochemical analysis and/or Mass spectrometry analysis

Sponsors & Collaborators

  • Centro Hospitalar De São João, E.P.E.

    collaborator OTHER

  • Centro de Investigação em Tecnologias e Serviços de Saúde

    collaborator OTHER

  • Rede de Investigação em Saúde

    collaborator OTHER

  • Universidade do Porto

    lead OTHER

Principal Investigators

  • Elisabete Martins, MD, PhD · Universidade do Porto

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-06-01
Primary Completion
2024-06-01
Completion
2025-06-01

Countries

  • Portugal

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05409833 on ClinicalTrials.gov