Exploratory Study on Combined Conversion Immunotherapy for Liver Metastasis of MSS Type Initial Unresectable Colorectal Cancer Based on Gene Status
NCT05409417 · Status: UNKNOWN · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 40
Last updated 2022-06-08
Summary
Evaluation of tislellimab combined with XELOX and bevacizumab or tislelizumab combined with FOLFOX and cetuximab regimen in patients with liver metastases from colorectal cancer Rate and R0 resection rate and safety.
Conditions
- Colorectal Cancer
- Liver Metastases
Interventions
- DRUG
-
Experimental drug
Tilelizumab combined with XELOX and bevacizumab or tislelizumab combined with FOLFOX and cetuximab
Sponsors & Collaborators
-
Second Affiliated Hospital, School of Medicine, Zhejiang University
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-10-01
- Primary Completion
- 2024-02-01
- Completion
- 2024-09-01
Countries
- China
Study Locations
More Related Trials
-
Phase II Study of Tislelizumab Combined With Cetuximab and Irinotecan in the Treatment of Recurrent, Refractory mCRC
NCT05143099 ·Status: UNKNOWN ·Phase: PHASE2
-
Camrelizumab Combined With Apatinib 、XELOX 、RFA in the Treatment of Liver Metastases of Colorectal Cancer
NCT04202978 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Efficacy and Safety Study of a Modified XELOX Regimen in First-Line Treatment of Metastatic Colorectal Adenocarcinoma
NCT01552967 ·Status: UNKNOWN ·Phase: PHASE2
-
Chemotherapy With Cetuximab as Conversion Therapy in RAS/BRAF WT Unresectable Liver Metastasis Right-sided Colon Cancer
NCT06322147 ·Status: RECRUITING
-
Cetuximab Monotherapy Maintenance Treatment in mCRC
NCT02978313 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
An Observational Study of Bevacizumab in Combination With 5-FU-Based Chemotherapy in Chinese Participants With Metastatic Colorectal Cancer
NCT01319877 ·Status: COMPLETED
-
A Small-sample, Real-world Study of Sintilimab Plus Bevacizumab/Cetuximab Plus XELOX Regimen for Conversion Therapy in Patients With Advanced Colorectal Cancer
NCT05544812 ·Status: UNKNOWN
-
Chemokine-Modulatory Regimen for Recurrent Resectable Colorectal Cancer
NCT01545141 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Phase II Clinical Study of the Efficacy and Safety of Tislelizumab Combined With Fruquintinib and Chidamide in the Treatment of Unresectable or Advanced Microsatellite Stabilized (MSS/pMMR) Colorectal Cancer With Liver Metastases
NCT06218888 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Regorafenib Plus PD-1 Inhibitor in Patients With Colorectal Cancer
NCT04110093 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Regorafenib and XELOX as 2nd Line Treatment in Metastatic Colorectal Cancer
NCT04008511 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Evaluate Efficacy and Safety of XELOX in Potentially Resectable Liver Metastasis From Colorectal Cancer(CRC)
NCT00997685 ·Status: UNKNOWN ·Phase: PHASE2
-
Recombinant Anti-tumor and Anti-virus Protein for Injection Plus Xeloda in Treatment of Metastatic Colorectal Cancer
NCT02068131 ·Status: UNKNOWN ·Phase: PHASE2
-
The Efficacy and Safety of Modified XELOX(mXELOX) Plus Cetuximab vs FOLFOX Plus Cetuximab in RAS and BRAF WT mCRC Pts
NCT05074966 ·Status: UNKNOWN ·Phase: PHASE3
-
ARQ 197 in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancer
NCT01075048 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Cetuximab & Celecoxib for Metastatic Colorectal Cancer or Colorectal Cancer That Cannot Be Removed by Surgery
NCT00466505 ·Status: COMPLETED ·Phase: PHASE2
-
The Safety and Efficacy of HAIC+Tislelizumab+Regorafenib in Patients With Colorectal Liver Metastases
NCT05877001 ·Status: UNKNOWN ·Phase: PHASE2
-
Intermittent Versus Continuous Tarceva Study
NCT01243047 ·Status: COMPLETED ·Phase: PHASE2
-
Cetuximab, Irinotecan, Toripalimab in RAS/BRAF Wild-type Ultraselected Right-sided Colorectal Cancer Study
NCT06547203 ·Status: RECRUITING ·Phase: PHASE2
-
Improving SUrgery of Liver Metastases: a Trial of the Arterial Chemotherapy Network
NCT03164655 ·Status: COMPLETED ·Phase: PHASE2
-
Study of CMAB009 to Treat KRAS Wild Type Metastatic Colorectal Cancer
NCT01550055 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Cetuximab as Salvage Therapy in Patients With Neo Wild-type RAS/RAF Metastatic Colorectal Cancer With Liver Metastases.
NCT04189055 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study Investigating the Efficacy and Safety of LBL-007 Plus Tislelizumab in Combination With Bevacizumab Plus Fluoropyrimidine Versus Bevacizumab Plus Fluoropyrimidine in Participants With Unresectable or Metastatic Colorectal Cancer
NCT05609370 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Cetuximab in Combination With Dabrafenib and Tislelizumab in BRAF Mutated Treatment of Advanced Colorectal Cancer
NCT05963087 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Raltitrexed-based Chemotherapy Plus Bevacizumab in Retreated Patients With Advanced Colorectal Cancer
NCT03126071 ·Status: UNKNOWN ·Phase: PHASE2