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Impact of TMAO Serum Levels on Hyperemic IMR in STEMI Patients

NCT05406297 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 400

Last updated 2022-08-16

No results posted yet for this study

Summary

Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite of dietary choline, L-carnitine, and phosphatidylcholine-rich foods. On the basis of experimental studies and patients with prevalent disease, elevated plasma TMAO may increase risk of atherosclerotic cardiovascular disease (ASCVD). However, to our knowledge, no data is available on its impact on coronary microcirculation.

Conditions

  • STEMI - ST Elevation Myocardial Infarction
  • Microvascular Coronary Artery Disease

Interventions

PROCEDURE

pressure-temperature sensor guidewire-based measurement

In brief, a 6-F angioplasty guiding catheter without side-holes will be used first used to engage the left main coronary artery. A pressure-temperature sensor guidewire ( PressureWire™ X Guidewire) will be used for physiology measurements including IMR measurements. Pressure measurement from the wire was first equalized with that of the guiding catheter. Then the pressure sensor will be positioned two-thirds of the way down the LAD artery. Intracoronary nitroglycerin will be administered (100 to 200 μg). Hyperemia will be induced with adenosine intracoronary injections.

Sponsors & Collaborators

  • Università degli Studi di Brescia

    collaborator OTHER

  • Kreiskrankenhaus Rotenburg

    collaborator UNKNOWN

  • Lithuanian University of Health Sciences

    lead OTHER

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-12
Primary Completion
2022-07-01
Completion
2022-08-01

Countries

  • Lithuania

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05406297 on ClinicalTrials.gov