Association of Silicone Breast Implants With Overall Wellbeingand Auto-immune Diseases

Summary

Background: Implant-based breast reconstructions contribute considerably to the quality of life of breast cancer patients. A knowledge gap exists concerning the potential role of breast implants in the development of so called 'breast implant illness' and autoimmune diseases in breast cancer survivors with a silicone breast implant-based reconstruction. Breast implant illness is a constellation of non-specific symptoms reported by a small group of women with silicone breast implants.

Methods/Design: The Areola study is a multi-centre historic cohort study with prospective follow-up aiming to assess the risk of 'breast implant illness' and autoimmune diseases in female breast cancer survivors with and without silicone breast implants. The cohort consists of breast cancer survivors who received surgical treatment with silicone implant-based reconstruction in six major hospitals across the Netherlands in the period between 2000 and 2015. As comparison group, a frequency-matched sample of breast cancer survivors without breast implants will be selected. An additional group of women who received breast augmentation surgery in the same years will be selected to compare their characteristics and health outcomes with those of breast cancer patients with implants. All women still alive will be invited to complete a web-based questionnaire covering various health related topics. The entire cohort including deceased women will be linked to the population based computerized databases of Statistics Netherlands. These databases include a registry of diagnostic codes, a pharmacotherapeutic prescriptions registry and a cause-of-death registry in which diagnoses of autoimmune diseases will be identified. Outcomes of interest are the prevalence and incidence of BII and the prevalence and incidence of autoimmune diseases. In addition, risk factors for the development of BII and autoimmune disorders will be assessed among women with implants.

Discussion: The Areola study will contribute to the availability of reliable information on the risks of breast implant illness and autoimmune diseases in Dutch breast cancer survivors with silicone breast implants. This will inform breast cancer survivors and aid future breast cancer patients and their treating physicians to make informed decisions about reconstructive strategies after mastectomy.

Keywords: Silicone breast implants, Breast reconstruction, Breast cancer, Breast Implant Illness, Autoimmune disease

Conditions

• Breast Cancer
• Breast Implant; Complications
• Autoimmune Diseases

Interventions

PROCEDURE

Breast reconstruction with silicone breast implant

(i) mastectomy followed by immediate implant-based reconstruction, (ii) mastectomy followed by implant-based reconstruction at a later stage and (iii) latissimus dorsi flap reconstruction with a silicone breast implant.

PROCEDURE

Breast conserving surgery/Mastectomy/Autologous reconstruction

(iv) simple mastectomy without reconstruction, (v) autologous reconstruction and (vi) breast conserving surgery,

PROCEDURE

Breast Augmentation

(vii) cosmetic augmentation with silicone breast implants

Sponsors & Collaborators

• Erasmus Medical Center

  collaborator OTHER

• Maastricht University Medical Center

  collaborator OTHER

• Zuyderland Medical Centre

  collaborator OTHER

• Medisch Spectrum Twente

  collaborator OTHER

• Ziekenhuisgroep Twente

  collaborator OTHER

• Velthuis Kliniek

  collaborator UNKNOWN

• The Netherlands Cancer Institute

  lead OTHER

Principal Investigators

• Floor van Leeuwen, PhD · The Netherlands Cancer Institute

• Marie-Jeanne Vrancken Peeters, PhD · The Netherlands Cancer Institute

• Eveline Bleiker · The Netherlands Cancer Institute

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-07-01

Primary Completion

2024-06-01

Completion

2025-06-01

Countries

• Netherlands

Study Locations