Cannabis' Impact on Alcohol Consumption

Summary

This study employs a repeated measures experimental design to examine the effect of THC-dominant dose of cannabis and CBD-dominant dose of cannabis, relative to placebo, on subsequent drinking in an alcohol choice task in which participants choose either to drink or receive monetary reinforcement for drinks not consumed. Cannabis will be administered simultaneously with an alcohol-priming dose or alcohol placebo.

The study will enroll up to 350 nontreatment-seeking heavy episodic alcohol drinkers who use cannabis weekly.

Conditions

• Alcohol Drinking
• Cannabis Use
• Cannabis
• Alcohol Use Disorder

Interventions

DRUG

THC-dominant cannabis

Smoked cannabis with 9.53% THC and 0.09% CBD

DRUG

CBD-dominant cannabis

Smoked cannabis with 0.35% THC and 11.27% CBD

DRUG

Cannabis placebo

Smoked placebo cannabis plant material

DRUG

Alcohol

Drink containing 0.3 g/kg of alcohol

DRUG

Alcohol placebo

Placebo beverage contains only juice and a negligible trace of alcohol for masking

Sponsors & Collaborators

• National Institute on Alcohol Abuse and Alcoholism (NIAAA)

  collaborator NIH

• Brown University

  lead OTHER

Principal Investigators

• Jane Metrik, PhD · Brown University

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Model

FACTORIAL

Eligibility

Min Age

21 Years

Max Age

50 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-03-16

Primary Completion

2027-03-31

Completion

2027-03-31

FDA Drug

Yes

Countries

• United States

Study Locations