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Olfactory Training on Smell Dysfunction Patients in HK

NCT05364125 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2025-06-03

No results posted yet for this study

Summary

* Causes of olfactory dysfunction can be classified into conductive and sensorineural causes.
* Conductive causes are mainly due to structural nasal problem, which can be treated by nasal surgery
* Sensorineural causes included post-infection, post-head injury, post Head and Neck irradiation and other central nervous system diseases.
* Olfactory Training is well established treatment for sensorineural olfactory dysfunction in foreign countries.
* Olfactory Training by neurological chemosensory stimulation using aromatic substances delivered via electronic portable aromatic rehabilitation (EPAR) diffuser was proved to be effective treatment in COVID-19 related olfactory dysfunction in recent Hong Kong study.
* However, there is a lack of local study on the effect of Olfactory Training in other non-COVID-19 sensorineural causes of olfactory dysfunction in Hong Kong population.

Conditions

  • Olfaction Disorders
  • Smell Disorders
  • Anosmia
  • Hyposmia
  • Olfactory Impairment
  • Smell Loss
  • Smell Dysfunction

Interventions

OTHER

Olfactory Training

Four aromatic substances will be used (Citrus limon, Eucalyptus radiata, Pelargonium graveolens, Juniperus virginiana)

OTHER

Control

Normal Saline will be used

Sponsors & Collaborators

  • Pamela Youde Nethersole Eastern Hospital

    lead OTHER

Principal Investigators

  • Kai Chuen Fergus Wong, FRCSEd(ORL) · Pamela Youde Nethersole Eastern Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-07-01
Primary Completion
2027-06-30
Completion
2027-06-30

Countries

  • Hong Kong

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05364125 on ClinicalTrials.gov