A Study of JNJ-77242113 for the Treatment of Moderate-to-Severe Plaque Psoriasis
NCT05357755 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 90
Last updated 2026-05-05
Summary
The purpose of the study is to evaluate the efficacy of an oral tablet formulation of JNJ-77242113 compared with placebo in participants with moderate-to-severe plaque psoriasis.
Conditions
Interventions
- DRUG
-
JNJ-77242113
JNJ-77242113 will be administered orally as delayed release tablets.
- DRUG
-
Matching placebo will be administered orally as delayed release tablets.
Sponsors & Collaborators
-
Janssen Research & Development, LLC
lead INDUSTRY
Principal Investigators
-
Janssen Research & Development, LLC Clinical Trial · Janssen Research & Development, LLC
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- DOUBLE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-06-13
- Primary Completion
- 2023-03-23
- Completion
- 2023-04-10
- FDA Drug
- Yes
Countries
- United States
- Canada
- France
- Germany
- Poland
- Spain
Study Locations
More Related Trials
-
A Study of JNJ-77242113 for the Treatment of Participants With Plaque Psoriasis Involving Special Areas (Scalp, Genital, and/or Palms of the Hands and the Soles of the Feet)
NCT06095102 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
The Efficacy and Safety of TLL018 in Moderate-to-severe Plaque Psoriasis
NCT05772520 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis (ICONIC-ADVANCE 2)
NCT06220604 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
A Study to Evaluate Efficacy and Safety of HS-10374 for Moderate to Severe Plaque Psoriasis
NCT06077331 ·Status: RECRUITING ·Phase: PHASE2
-
A Study to Evaluate the Efficacy and Safety/Tolerability of Subcutaneous Tildrakizumab (SCH 900222/MK-3222) in Participants With Moderate-to-Severe Chronic Plaque Psoriasis Followed by a Long-term Extension Study (MK-3222-011)
NCT01729754 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Confirm Efficacy and Safety of HS-10374 for Moderate to Severe Plaque Psoriasis
NCT06672393 ·Status: NOT_YET_RECRUITING ·Phase: PHASE3
-
Dose Ranging Study of the Safety and Efficacy of R115966 in Plaque Psoriasis
NCT00716144 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Test How Well Patients With Plaque Psoriasis Tolerate BI 730357 Over a Longer Period and How Effective it is
NCT03835481 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of JNJ-77242113 for the Treatment of Participants With Generalized Pustular Psoriasis or Erythrodermic Psoriasis
NCT06295692 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
A Study of LY3972406 in Adult Participants With Moderate-to-Severe Plaque Psoriasis
NCT06176768 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Determine the Optimal Dose of Tildrakizumab (SCH 900222/MK-3222) for the Treatment of Moderate-to-severe Chronic Plaque Psoriasis (P05495) (MK-3222-003)
NCT01225731 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Evaluate Efficacy and Safety of HS-10374 for Mild-to-moderate Plaque Psoriasis
NCT06926582 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Study to Evaluate the Safety and Efficacy of JTE-051 in Subjects With Moderate to Severe Plaque Psoriasis
NCT03358290 ·Status: TERMINATED ·Phase: PHASE2
-
A Study Comparing AIN457 to Placebo in Subjects With a Diagnosis of Moderate to Severe Stable Plaque Psoriasis
NCT00669916 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Safety and Efficacy of TLL018 in Patients With Plaque Psoriasis
NCT05342428 ·Status: COMPLETED ·Phase: PHASE1
-
Efficacy and Safety of Subcutaneous Secukinumab for Moderate to Severe Chronic Plaque-type Psoriasis for up to 1 Year
NCT01365455 ·Status: COMPLETED ·Phase: PHASE3
-
Study to Investigate the Safety, Tolerability, Absorption, Distribution, Metabolism, and Elimination of RWJ-445380 Administered to Patients With Plaque Psoriasis
NCT00396422 ·Status: COMPLETED ·Phase: PHASE2
-
An Observational Study to Evaluate Patient-Reported Experiences of Living With Moderate-to-Severe Plaque Psoriasis
NCT01555606 ·Status: COMPLETED
-
A Study to Evaluate the Benefit and Safety of GSK2982772 in Moderate to Severe Psoriasis Participants
NCT04316585 ·Status: COMPLETED ·Phase: PHASE1
-
Clinical Study to Evaluate the Efficacy and Safety of DSXS in Patients With Mild to Moderate Plaque Psoriasis
NCT02618759 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Evaluate Safety and Efficacy of Toreforant (JNJ-38518168) in Participants With Moderate to Severe Plaque-type Psoriasis
NCT02295865 ·Status: COMPLETED ·Phase: PHASE2
-
Proof of Concept Study of AX-158 in Patients With Mild to Moderate Plaque Psoriasis
NCT05725057 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of BMS-582949 in Patients With Moderate to Severe Plaque Psoriasis
NCT00399906 ·Status: COMPLETED ·Phase: PHASE2
-
Study to Evaluate PF-04965842 in Patients With Moderate to Severe Psoriasis
NCT02201524 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of Guselkumab in the Treatment of Participants With Moderate to Severe Plaque-Type Psoriasis With Randomized Withdrawal and Retreatment
NCT02207244 ·Status: COMPLETED ·Phase: PHASE3