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Association Between Prescription of Antidepressants and Delirium in the Elderly : Analysis From the World Health Organization Global Database

NCT05356078 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 10000

Last updated 2022-05-02

No results posted yet for this study

Summary

Delirium is a frequent reason for hospitalisation of the elderly. Associations between the prescription of some medicines and the risk of delirium have already been demonstrated.

Antidepressants are widely prescribed in the elderly because of the frequency of anxiety-depressive symptoms in this population, where there are high pharmacokinetic and pharmacodynamic variability.

However, the association between antidepressants and the risk of delirium remains poorly understood.

Based on the analysis from the World Health Organization global database, the main objective of this study is to investigate the association between the different classes of antidepressants and the occurrence of the " delirium " event reported in the database.

A disproportionality analysis will be performed. It will aim to assess whether some classes of antidepressants, and within these classes some molecules, are associated with a greater risk of delirium.

Conditions

  • Antidepressive Agents
  • Aged
  • Delirium

Interventions

DRUG

Antidepressant

"Delirium" event reported in the World Health Organization global database in subjects aged over 65 years taking antidepressants, comparative analysis by antidepressant class

Sponsors & Collaborators

  • University Hospital, Caen

    lead OTHER

Eligibility

Min Age
65 Years
Max Age
120 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-01-03
Primary Completion
2022-02-03
Completion
2022-06-03

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05356078 on ClinicalTrials.gov