Personalized Diet-driven Microbiota Alterations as a Tool for Improving Mood Status in Elderly

Summary

The propose of the study is a multi-disciplinary project connecting nutritional and health sciences with social and behavioral sciences, and aimed at understanding the microbiota changes related to the third age and their effects on mood and mental health. The research aims are primarily practical: They will explore the influence of the gut flora on depression, which could help us to recommend diets that might reduce the risk of developing depression. The novelty of this proposal is in the design of personalized diet-driven microbiota alterations and health status to modulate depression in elderly. For the first time the improvement of mental health in the elderly will be studied through a nutritional and food habits approach based on microbiota changes upon ageing.

Conditions

• Depression

Interventions

BEHAVIORAL

Personalized Diet-driven microbiota

Based on the results of the individual microbiota profile, the investigators will formulate a specific diet aiming to enrich the distinct microbiota with organisms correlated to better mental health. The dietitian will visit each participant twice a month.

BEHAVIORAL

General information on nutrition and health

General information on nutrition and health. The dietitian will visit each participant twice a month.

Sponsors & Collaborators

• Shamir Research Institute

  collaborator UNKNOWN

• Clalit Health Services

  collaborator OTHER

• Migal, Galilee Technology Center

  collaborator OTHER

• Tel Hai College

  lead OTHER

Principal Investigators

• Ariella Ofran, M.D, MPH · Clalit Health Services

• Snait Tamir, Prof. · Migal, Galilee Technology Center

• Shmuel Shamai, Prof. · Shamir Research Institute

• Adi Vitman- Schorr, Ph.D · Shamir Research Institute

• Karen Jackson, Ph.D · Migal, Galilee Technology Center

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

60 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2017-09-11

Primary Completion

2020-12-30

Completion

2021-02-01

Countries

• Israel

Study Locations