MedTrace Logo

The Effect of SGLT2 Inhibitors on Cognitive Functions and BDNF Levels in Patients With Type 2 Diabetes

NCT05341388 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 25

Last updated 2022-04-22

No results posted yet for this study

Summary

Cognitive impairment is a common complication in diabetes for various reasons. Although glycemic control improves cognitive impairment, different antidiabetic medications' effects on cognitive functions are still being investigated. Brain-derived neurotrophic factor (BDNF) is a neuroinflammatory marker and a member of the neurotrophin family with growth factor properties. BDNF levels have been shown to decrease in mild cognitive dysfunction or in late-onset Alzheimer's disease. Our aim is to examine the effect of SGLT2 inhibitor use on cognitive functions and BDNF levels.

Conditions

Interventions

DIAGNOSTIC_TEST

MOCA cognitive evaluation test

Before starting their newly prescribed medication, we will apply MOCA and repeat it at the end of the trial.

DIAGNOSTIC_TEST

BDNF levels

Before starting their newly prescribed medication, we will apply MOCA and repeat it at the end of the trial.

OTHER

SF-36 test

Before starting their newly prescribed medication, we will apply MOCA and repeat it at the end of the trial.

DIAGNOSTIC_TEST

Geriatric depression test

Before starting their newly prescribed medication, we will apply MOCA and repeat it at the end of the trial.

Sponsors & Collaborators

  • Goztepe Training and Research Hospital

    lead OTHER

Principal Investigators

  • Ayse N Erbakan, MD · Istanbul Medeniyet University Goztepe Research and TRaining Hospital

  • Mehmet Sargın, Prof · Istanbul Medeniyet University

  • Nazmiye Özbilgin, Prof · University of Health Sciences Siyami Ersek TCS Training and Research Hospital

  • Aytekin Oğuz, Prof · Istanbul Medeniyet University

Eligibility

Min Age
60 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-03-01
Primary Completion
2021-11-30
Completion
2021-11-30

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05341388 on ClinicalTrials.gov