Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age

Summary

Despite improved survival of extremely premature infants in recent decades, neonatal intensive care unit (NICU) graduates are diagnosed with asthma, sleep disordered breathing (SDB) in childhood, and neurodevelopmental impairments (NDI) at significant rates, disproportionate to their term peers. Early detection and intervention are critical to mitigate the impact of these impairments. Mechanisms leading from premature birth to these undesirable outcomes remain unclear, and accurate prognostic measures are lacking.

This study wants to learn if these problems are related to certain patterns of breathing that babies had while they were in the NICU.

Conditions

• Premature Birth
• Asthma in Children
• Sleep-Disordered Breathing
• Neurodevelopmental Disorders

Sponsors & Collaborators

• University of Virginia

  collaborator OTHER

• Case Western Reserve University

  collaborator OTHER

• University of Miami

  collaborator OTHER

• Northwestern University

  collaborator OTHER

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• University of Alabama at Birmingham

  collaborator OTHER

• Ann & Robert H Lurie Children's Hospital of Chicago

  lead OTHER

Principal Investigators

• Debra Weese-Mayer, MD · Ann & Robert H Lurie Children's Hospital of Chicago

• Anna Maria Hibbs, MD · Case Western Reserve University

• Ambalavanan Namasivayam, MD · University of Alabama at Birmingham

• Nelson Claure, MSc, PhD · University of Miami

• Randall Moorman, MD · University of Virginia

Eligibility

Min Age

30 Weeks

Max Age

83 Months

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-11-01

Primary Completion

2026-06-30

Completion

2026-06-30

Countries

• United States

Study Locations