Effect of Glycopyrronium in Combination With Tropisetron in Anti-postoperative Nausea and Vomiting

Summary

To compare the anti-nausea and vomiting effect between glycopyrronium in combination with tropisetron and normal saline in combination with tropisetron for patients receiving elective surgery under general anesthesia. Based on this study the investigators intend to explore the feasibility of using glycopyrronium as adjuvant drug to prevent postoperative nausea and vomiting.

Conditions

• Postoperative Nausea and Vomiting

Interventions

DRUG

Glycopyrronium in Combination With Tropisetron

Glycopyrronium (0.2mg) in Combination With Tropisetron (4mg) intravenously given at the ending of the surgery.

DRUG

Normal Saline in Combination With Tropisetron

Normal Saline in Combination With Tropisetron (4mg) intravenously given at the ending of the surgery.

Sponsors & Collaborators

• Chongqing General Hospital

  collaborator OTHER

• Chongqing Medical University

  collaborator OTHER

• The People's Hospital of DAZU ，Chongqing

  collaborator UNKNOWN

• The People's Hospital of Chongqing Kaizhou District

  collaborator UNKNOWN

• Fuling Hospital affiliated to Chongqing University

  collaborator UNKNOWN

• Qianjiang Central Hospital of Chongqing

  collaborator UNKNOWN

• Stomatological Hospital of Chongqing Medical University

  collaborator UNKNOWN

• People's Hospital of Changshou Chongqing

  collaborator UNKNOWN

• The Ninth People's Hospital of Chongqing

  collaborator UNKNOWN

• The First People's Hospital Of Chongqing Liang Jiang New Area

  collaborator UNKNOWN

• People's Hospital of Xiushan County

  collaborator UNKNOWN

• Wushan County People's Hospital

  collaborator UNKNOWN

• Three Gorges Hospital of Chongqing University

  collaborator OTHER

• First Affiliated Hospital of Chongqing Medical University

  collaborator OTHER

• Department of Anesthesiology, Daping Hospital, Institute of Surgery Research, the Army Medical University

  collaborator UNKNOWN

• The People's Hospital of Nanchuan

  collaborator UNKNOWN

• Chongqing Traditional Chinese Medicine Hospital

  collaborator OTHER

• People's Hospital of Shapingba District， Chongqing

  collaborator UNKNOWN

• Chongqing Liangping District People's Hospital

  collaborator UNKNOWN

• Chongqing Jiangbei Hospital of Traditional Chinese Medicine

  collaborator UNKNOWN

• People's Hospital of Chongqing Hechuan

  collaborator UNKNOWN

• The Second Affiliated Hospital of Chongqing Medical University

  lead OTHER

Principal Investigators

• He Huang, MD · The Second Affiliated Hospital, Chongqing Medical University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-04-21

Primary Completion

2023-06-30

Completion

2023-06-30

Countries

• China

Study Locations