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Study on the Association Between Vitamin C Deficiency and Diarrhea in Children

NCT05328037 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 288

Last updated 2026-02-03

No results posted yet for this study

Summary

Diarrheal disease is the second leading cause of death in children under five, althought it is both preventable and treatable. The causative factors of diarrheal diseases vary a lot from region to region (bacteria, viruses, parasites). Diarrhea is one of the main causes of malnutrition in children under five years of age. Inversely, nutritional deficiency, particularly vitamin C deficiency, can be a risk factor for diarrhea.

The main objective of this study is to assess the impact of vitamin C deficiency on diarrheal infection in children aged 2 to 5 years in countries with a high diarrheal rate. This pilot case-control study will be conducted in metropolitan France, Africa and South America. This question will be addressed by comparing vitamin C levels in children with diarrhea, regardless of the infectious agent, to levels in age- and sex-matched controls.

Conditions

Interventions

DIAGNOSTIC_TEST

Blood sample collection

Blood sample collection for dosage of vitamin C

Sponsors & Collaborators

  • Institut Cochin

    collaborator OTHER

  • University of Copenhagen

    collaborator OTHER

  • Institut Pasteur

    lead INDUSTRY

Principal Investigators

  • Alexandre Manirakiza, MD, PhD · Institut Pasteur de Bangui, Centrafrican Republic

  • Thomas Blanc, MD, PhD · Hopital Necker Paris, France

  • Jean-Chrysostome Gody, MD, PhD · Complexe Pédiatrique de Bangui, Centrafrican Republic

  • Emilie Huguon, MD · Centre Hospitalier Térritorial Gaston Bourret, New Caledonia

Eligibility

Min Age
18 Months
Max Age
60 Months
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-04-25
Primary Completion
2024-03-25
Completion
2024-03-25

Countries

  • Central African Republic
  • France
  • New Caledonia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05328037 on ClinicalTrials.gov