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Functional Outcomes From Diets in Multiple Sclerosis

NCT05327322 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2026-04-03

No results posted yet for this study

Summary

The purpose of this study is to test the effects of two dietary interventions, glycemic load and calorie restriction, on physical function, cognition, pain, fatigue, mood, and anxiety in adults with multiple sclerosis (MS). The investigators will also explore the how the diet interventions impact inflammation, immunity, and metabolic biomarkers.

Conditions

  • Relapsing Remitting Multiple Sclerosis
  • Secondary Progressive Multiple Sclerosis

Interventions

BEHAVIORAL

Glycemic load

Participants will be provided food to meet GL prescription for the duration of the trial.

BEHAVIORAL

Calorie restriction

Participants will be provided food to meet their prescribed daily calorie intake for the duration of the trial (weight stable in first 16 weeks, weight loss in second 16 weeks).

BEHAVIORAL

Behavioral support

All participants will receive behavioral supports in the form of email, text, information pages and weekly calls from the study staff to maximize adherence.

Sponsors & Collaborators

  • Washington University School of Medicine

    collaborator OTHER

  • United States Department of Defense

    collaborator FED

  • University of Alabama at Birmingham

    lead OTHER

Principal Investigators

  • Brooks Wingo, PhD · University of Alabama at Birmingham

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-03-20
Primary Completion
2026-11-01
Completion
2026-11-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05327322 on ClinicalTrials.gov