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Comparing the Effects of Psilocin and Psilocybin in Healthy Adults

NCT05317689 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2025-06-10

No results posted yet for this study

Summary

To compare the physiological and psychological effects of psilocin taken orally by pill or sublingually by dissolving a tablet under the tongue to those of psilocybin taken by pill in healthy adults.

Conditions

  • Healthy

Interventions

DRUG

Psilocin

17.5mg oral psilocin with psychological support and physiological monitoring

DRUG

Psilocybin

25mg oral psilocybin with psychological support and physiological monitoring

DRUG

Sublingual Psilocin

2.18mg - 4.36mg sublingual psilocin with psychological support and physiological monitoring

Sponsors & Collaborators

Principal Investigators

  • Joshua Woolley, MD/PhD · University of California, San Francisco

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
25 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-05-26
Primary Completion
2025-01-16
Completion
2025-07-31
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Drugs
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05317689 on ClinicalTrials.gov