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Early Detection of Neuropathy in ATTRv

NCT05311488 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 47

Last updated 2026-03-12

No results posted yet for this study

Summary

The purpose of the study is to evaluate and compare different tools that are used to detect evidence of peripheral neuropathy in patients with TTRv.

Conditions

  • Hereditary Amyloidosis, Transthyretin-Related

Interventions

DIAGNOSTIC_TEST

neurofilament light chain

Blood test

DIAGNOSTIC_TEST

In-vivo Meissner Corpuscle imaging

Imaging

DIAGNOSTIC_TEST

Nerve conduction study

Nerve conduction study

Sponsors & Collaborators

Principal Investigators

  • Chafic Karam, MD · University of Pennsylvania

  • Brian Drachman · University of Pennsylvania

  • Sami Khella, MD · University of Pennsylvania

  • Janice Pieretti, MD · University of Pennsylvania

Eligibility

Min Age
30 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-02-14
Primary Completion
2025-11-01
Completion
2026-02-14

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05311488 on ClinicalTrials.gov