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Nutritional Intervention and DNA Damage of Patients With HBOC

NCT05306002 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 34

Last updated 2024-03-05

No results posted yet for this study

Summary

Breast and Ovarian Cancer Syndrome (HBOC) is characterized by mutations in tumor suppressor genes such as BRCA1 and BRCA2, which increase the carrier's risk of developing breast and ovarian cancer, especially before 40. In this pathology the DNA damage is increased because there is a state of chronic inflammation, plus the antineoplastic treatments and changes in body composition result in oxidative stress. The inductions of epigenetic changes by a nutritional intervention with an specific distribution of macronutrients, micronutrients and polyphenols, not only ensures an optimal nutritional status, but also shows a decrease in oxidative stress, and therefore in DNA damage. The aim of this study is to assess if the DNA damage in patients with HBOC decreases after the nutritional intervention.

Conditions

  • HBOC Syndrome
  • DNA Damage
  • Nutrition Therapy

Interventions

COMBINATION_PRODUCT

Antioxidant therapy

Antioxidant therapy based in the following dietary components: Zinc, Selenium, Magnesium, carotenoids, indole-3-carbinol, curcumin, epigalactocatechin, caffeine, resveratrol, lycopene, genistein, phytoestrogens

Sponsors & Collaborators

  • Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado

    lead OTHER_GOV

Principal Investigators

  • María Fernanda Díaz Yáñez, BSc · CMN "20 de Noviembre"

  • Martha Fernanda Medero López, BSc · CMN "20 de Noviembre"

  • Juan Antonio Pineda Juárez, PhD · CMN "20 de Noviembre"

  • Martha Orozco Quiyono, MSc · CMN "20 de Noviembre"

  • Mónica Escamilla Tilch, PhD · CMN "20 de Noviembre"

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-11-28
Primary Completion
2020-03-22
Completion
2022-12-31

Countries

  • Mexico

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05306002 on ClinicalTrials.gov