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Cell-free Autologous Regenerative Endodontics Treatment for Teeth With Periapical Lesions (CARETT)

NCT05305417 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 228

Last updated 2022-03-31

No results posted yet for this study

Summary

Conventional endodontic treatment has been the treatment of choice for the management of signs and symptoms of mature permanent teeth with pulpal necrosis and periapical lesion with predictable and favorable results. However, treatment outcomes have not shown improvement or innovation in decades. The main objective of this study is to evaluate the clinical effectiveness of a regenerative endodontic procedure (cell-free and autologous protocol) versus conventional endodontics in the resolution of signs and symptoms of periapical lesion and pulp vitality-sensitivity in mature permanent teeth with a diagnosis of pulpal necrosis and periapical lesion.

Conditions

  • Periapical Diseases
  • Pulp Necroses

Interventions

PROCEDURE

Autologous Regenerative Endodontic Treatment

The intervention consist in achieve an access to the teeth root canal system, do a chemico-mechanical preparation each root canal for to be obturated with an autologous biological scaffold and bioactive biomaterials to maintain teeth free of signs/symptoms caused by pulp necroses and periapical lesions

PROCEDURE

Conventional Root Canal Treatment

The intervention consist in achieve an access to the teeth root canal system, do a chemico-mechanical preparation each root canal for to be obturated with an inert biomaterial to maintain teeth free of signs/symptoms caused by pulp necroses and periapical lesions

Sponsors & Collaborators

  • Universidad de Valparaiso

    lead OTHER

Principal Investigators

  • Alicia Caro, MSC, DDS · Department of Endodontics, Faculty of Dentistry, University of Valparaíso, Chile.

  • Juan Caro, DDS · Department of Endodontics, Faculty of Dentistry, University of Valparaíso, Chile.

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-03-31
Primary Completion
2024-03-31
Completion
2025-03-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05305417 on ClinicalTrials.gov