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Translational Immunodiagnostics in Stroke (TrImS)

NCT05300997 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 650

Last updated 2026-05-11

No results posted yet for this study

Summary

In adult patients presenting to emergency departments within 24 hours of symptom onset with suspected acute stroke, we aim:

1. to identify early brain- and pathology-specific circulating, whole blood, plasma and serum panorOmic biomarkers that enable early acute stroke detection, diagnosis, dynamics, differentiation, monitoring, prediction and prognosis.
2. to identify early brain- and pathology-specific, panorOmic biomarkers in saliva that enable early acute stroke detection, diagnosis, dynamics, differentiation, monitoring, prediction and prognosis.
3. to derive biomarker platforms of models for early acute stroke detection, diagnosis, dynamics, differentiation, monitoring, prediction and prognosis
4. to validate these models in independent and external datasets

Conditions

  • Acute Ischemic Stroke
  • Haemorrhagic Stroke
  • Transient Ischemic Attacks
  • Cardioembolic Stroke
  • Large-Artery Atherosclerosis (Embolus/Thrombosis)
  • Small Vessel Disease
  • Stroke of Other Determined Etiology
  • Stroke of Undetermined Etiology
  • Atrial Fibrillation
  • Stroke of Anterior Cerebral Artery
  • Stroke of Middle Cerebral Artery
  • Stroke of Basilar Artery

Interventions

DIAGNOSTIC_TEST

Biomarker blood draw and saliva collection

Three peripheral 10mL blood sample (if available) Three 1 - 3mL salivary samples (if available)

Sponsors & Collaborators

  • The University of Hong Kong

    lead OTHER

Principal Investigators

  • Timothy H Rainer, MD · The University of Hong Kong

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-05-01
Primary Completion
2027-08-31
Completion
2027-08-31

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05300997 on ClinicalTrials.gov