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EXERT: Exercise Physiology After Thrombosis

NCT05296499 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 56

Last updated 2022-03-25

No results posted yet for this study

Summary

Deep vein thrombosis (DVT) can cause long-term scarring and narrowing of veins. When there is extensive damage to the veins in the legs, groin or abdomen it can affect the way that blood is able to flow back up to the heart. Some patients are left with severe symptoms such as pain, leg swelling and ulcers, and have surgical treatment with nitinol stents to re-open the veins and relieve symptoms. The primary aim of this study is to investigate venous blood flow to the heart during exercise in patients with extensive damage to the veins in the groin and abdomen after DVT, and changes that happen after stenting.

Conditions

  • Venous Thrombosis Deep (Limbs)
  • Post Thrombotic Syndrome

Interventions

DIAGNOSTIC_TEST

Cardiopulmonary exercise test (CPET)

Cardiopulmonary exercise testing using cycle ergonomenter

DIAGNOSTIC_TEST

Exercise cardiac MRI

Exercise cardiac MRI using supine cycle, participants exercised to peak workload as determined by CPET

OTHER

6 minute walk test

6MWT

DIAGNOSTIC_TEST

Blood tests

FBC, U\&E, LFTS

OTHER

Quality of life questionnaires

SF36, EQ5D, VEINES-QoL/Sym

OTHER

Repeat baseline assessments

repeat baseline

DIAGNOSTIC_TEST

MR venogram

MRI scan of venous system

Sponsors & Collaborators

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-09-20
Primary Completion
2022-10-20
Completion
2023-04-20

Countries

  • United Kingdom

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05296499 on ClinicalTrials.gov