Application of Linaclotide Capsule in Bowel Preparation for Colonoscopy

Summary

The clinical purpose of this study was to investigate whether the adjuvant application of linaclotide in bowel preparation for colonoscopy could improve the quality of bowel preparation or reduce the dosage of laxatives.

Conditions

• Bowel Preparation for Colonoscopy

Interventions

DRUG

3L PEG + Linaclotide

Before colonoscopy, particpant take linaclotide capsules for 3 days (1 tablet should be taken at least 30 minutes before the first meal every day). Particpant take 1500ml polyethylene glycol electrolyte solution within 1.5 hours from 20 p.m the night before the examination; and repeat the same dose of polyethylene glycol electrolyte solution 4-6 hours before colonoscopy.

DRUG

3L PEG

Particpant take 1500ml polyethylene glycol electrolyte solution within 1.5 hours from 20 p.m the night before the examination; and repeat the same dose of polyethylene glycol electrolyte solution 4-6 hours before colonoscopy.

DRUG

2L PEG + Linaclotide

Before colonoscopy, particpant take linaclotide capsules for 3 days (1 tablet should be taken at least 30 minutes before the first meal every day). Particpant take 1000ml polyethylene glycol electrolyte solution within 1 hours from 20 p.m the night before the examination; and repeat the same dose of polyethylene glycol electrolyte solution 4-6 hours before colonoscopy.

Sponsors & Collaborators

• Shanxi Provincial People's Hospital

  collaborator OTHER_GOV

• 900 Hospital of Joint Logistics Support Force of PLA

  collaborator OTHER

• Ruijin Hospital

  collaborator OTHER

• The First Affiliated Hospital of Nanchang University

  collaborator OTHER

• Qilu Hospital of Shandong University

  collaborator OTHER

• The Affiliated Hospital of Qingdao University

  collaborator OTHER

• The Third Affiliated Hospital of Wenzhou Medical University

  collaborator OTHER

• Affiliated Yueqing Hospital of Wenzhou Medical University

  collaborator OTHER

• The First Affiliated Hospital of Soochow University

  collaborator OTHER

• The 7th Medical Center of the PLA General Hospital

  collaborator UNKNOWN

• The First Hospital of Jilin University

  collaborator OTHER

• The Second Hospital of Hebei Medical University

  collaborator OTHER

• The Affiliated Hospital of Inner Mongolia Medical University

  collaborator OTHER

• The Second Affiliated Hospital of Dalian Medical University

  collaborator OTHER

• Ningxia Medical University General Hospital

  collaborator UNKNOWN

• Affiliated Hospital of Qinghai University

  collaborator OTHER

• Yunnan First People's Hospital

  collaborator UNKNOWN

• Xiangya Second Hospital, Central South University

  collaborator UNKNOWN

• Shanghai Zhongshan Hospital

  collaborator OTHER

• Daping Hospital, Army Military Medical University

  collaborator UNKNOWN

• Zunyi Medical College

  collaborator OTHER

• Huizhou Municipal Central Hospital

  collaborator OTHER

• Affiliated Hospital of Southwest Medical University

  collaborator OTHER

• The First Hospital of Shihezi University

  collaborator UNKNOWN

• Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

  collaborator OTHER

• Tangdu Hospital of Air Force Military Medical University

  collaborator UNKNOWN

• Changhai Hospital

  lead OTHER

Principal Investigators

• Zhaoshen Li · Changhai Hospital

Study Design

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2022-05-25

Primary Completion

2023-08-30

Completion

2024-04-28

Countries

• China

Study Locations