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Descemet Endothelial Thickness Comparison Trial I

NCT05289661 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 160

Last updated 2026-05-08

No results posted yet for this study

Summary

Descemet Endothelial Thickness Comparison Trial (DETECT) I is a multi-center, outcome assessor-masked, placebo-controlled clinical trial randomizing 160 patients in a 2x2 factorial design. The purpose of this study is to determine differences in visual outcomes between two types of corneal transplant surgeries, ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) and Descemet membrane endothelial keratoplasty (DMEK), and to determine the effect of rho-kinase inhibitors on endothelial cell loss.

Conditions

  • Fuchs

Interventions

DRUG

Topical Ripasudil

To determine the effect of rho-kinase inhibitors on endothelial cell loss

DRUG

Topical Placebo

topical Placebo

Sponsors & Collaborators

  • Oregon Health and Science University

    collaborator OTHER

  • University of California, San Francisco

    collaborator OTHER

  • University of California, Davis

    collaborator OTHER

  • Case Western Reserve University

    collaborator OTHER

  • Dartmouth-Hitchcock Medical Center

    collaborator OTHER

  • University of Pennsylvania

    collaborator OTHER

  • University of Miami

    collaborator OTHER

  • Wills Eye Hospital

    collaborator UNKNOWN

  • Stanford University

    lead OTHER

Principal Investigators

  • Jennifer Rose-Nussbaumer, MD · Stanford University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-07-15
Primary Completion
2026-11-30
Completion
2027-11-30
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05289661 on ClinicalTrials.gov