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Recovery Rate in Secondary Hypothyroidism

NCT05276856 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2024-08-21

No results posted yet for this study

Summary

The aim of this project is to assess the rate of recovery of secondary hypothyroidism in patients with pituitary disorders.

Conditions

  • Secondary Hypothyroidism

Interventions

DRUG

Levothyroxine

Step 1: * Reduce the dose of T4 therapy by 50% and recheck serum T4 after 2 weeks. * If serum T4 is normal, go to step 2. * If serum T4 drops to below normal then resume full T4 replacement (these patients will be considered as having withdrawal failure). Step 2: * Discontinue T4 therapy altogether and recheck serum TSH and T4 after 2 weeks. * If serum T4 is normal, go to step 3. * If serum T4 drops to below normal then resume full T4 replacement (these patients will be considered as having withdrawal failure). Step 3: * Recheck serum TSH and T4 after 8 weeks. * If serum TSH and T4 levels are normal, these patients will be regarded as having successful T4 withdrawal. * If T4 drops to below normal then resume full T4 replacement (these patients will be considered as having withdrawal failure).

Sponsors & Collaborators

  • Nova Scotia Health Authority

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-04-04
Primary Completion
2025-12-31
Completion
2025-12-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05276856 on ClinicalTrials.gov