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Ventilator-associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation

NCT05266066 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 590

Last updated 2025-06-19

No results posted yet for this study

Summary

The Ventilator Associated tracheobronchitis Initiative to Conduct Antibiotic evaluation (VATICAN) trial is a national, multicenter, non-inferiority trial in ICU patients comparing antibiotic treatment for 7 days versus clinical observation without antibiotic treatment for patients with ventilator-associated tracheobronchitis.

Conditions

  • Ventilator Associated Tracheobronchitis
  • Tracheobronchitis

Interventions

OTHER

Clinical observation without antibiotic therapy for VAT

Patients will receive standard care plus antibiotic if new organ dysfunction or new infections other than VAT.

OTHER

7 day antibiotic course for VAT

Patients will receive standard care plus 7 day course of antibiotic.

Sponsors & Collaborators

  • Hospital Israelita Albert Einstein

    collaborator OTHER

  • Hospital do Coracao

    collaborator OTHER

  • Hospital Moinhos de Vento

    collaborator OTHER

  • Hospital Alemão Oswaldo Cruz

    collaborator OTHER

  • BP - A Beneficência Portuguesa de São Paulo

    collaborator UNKNOWN

  • Brazilian Research in Intensive Care Network (BRICNet)

    collaborator UNKNOWN

  • Hospital Sirio-Libanes

    lead OTHER

Principal Investigators

  • Bruno M Tomazini, MD · Hospital Sírio-Libanês

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-07-11
Primary Completion
2026-11-01
Completion
2026-12-01

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05266066 on ClinicalTrials.gov