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ATP Level and Cough Sensitivity to ATP in Subjects With Refractory/Unexplained Chronic Cough

NCT05265871 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 131

Last updated 2025-05-11

Study results available
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Summary

This is a cross-sectional study to investigate ATP level in induced sputum and cough sensitivity to ATP in subjects with refractory/unexplained chronic cough. 60 patients with refractory/unexplained chronic cough and 30 matched healthy controls were recruited. Demographic data, clinical characteristic, cough sacles and medical history records were collected. Cough chanllage(ATP and capsaicin) and ATP measurement in sputum were conducted.The difference of sputum ATP level between patients and control and the correlation between sputum ATP level and cough sensitivity to ATP were analyzed.

Conditions

  • Refractory/Unexplained Chronic Cough

Sponsors & Collaborators

  • Kefang Lai

    lead OTHER

Principal Investigators

  • Kefang Lai, MD, PhD · Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-05-16
Primary Completion
2024-01-24
Completion
2024-01-24

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05265871 on ClinicalTrials.gov