NKG2D CAR-T Cells to Treat Patients With Previously Treated Liver Metastatic Colorectal Cancer
NCT05248048 · Status: UNKNOWN · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 9
Last updated 2022-02-21
Summary
Evaluate the clinical safety and feasibility of NKG2D CAR-T administrated by hepatic artery transfusion for patients with previously treated liver metastatic colorectal cancer.
Conditions
- Refractory Metastatic Colorectal Cancer
Interventions
- BIOLOGICAL
-
CAR-T infusion
NKG2D CAR-NK Cell Therapy in Patients With Refractory Metastatic Colorectal Cancer
Sponsors & Collaborators
-
Hangzhou Cheetah Cell Therapeutics Co., Ltd
collaborator OTHER -
The Third Affiliated Hospital of Guangzhou Medical University
lead OTHER
Principal Investigators
-
Xuehu Xu, MD · The Third Affiliated Hospital of Guangzhou Medical University
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2021-09-13
- Primary Completion
- 2022-10-31
- Completion
- 2022-10-31
Countries
- China
Study Locations
More Related Trials
-
CEA CAR-T Therapy After Cytoreduction in Colorectal Cancer Patients With Peritoneal Metastases
NCT07247396 ·Status: RECRUITING ·Phase: PHASE1
-
A Clinical Research of CAR T Cells Targeting CEA Positive Colorectal Cancer (CRC)
NCT04513431 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
Clinical Trial to Evaluate the Safety and Efficacy of IM96 CAR-T Cells Therapy in Patients With Advanced Digestive System Neoplasms
NCT05287165 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
Universal CAR-T Cells (REVO-UWD-01) for Metastatic Colorectal Cancer
NCT06653010 ·Status: SUSPENDED ·Phase: EARLY_PHASE1
-
Study of CEA Targeting CAR-T (PTC13) in the Treatment of CEA-Positive Advanced Malignant Solid Tumors
NCT06821048 ·Status: RECRUITING ·Phase: PHASE1
-
Safety and Efficacy of CEA-targeted CAR-T for CEA-positive Advanced Malignant Solid Tumors
NCT05538195 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Tumor Antigen-sensitized DC Vaccine for Colorectal Cancer Liver Metastases
NCT06545630 ·Status: RECRUITING ·Phase: PHASE1
-
Autologous CAR-T Cells (WD-01) for Metastatic Colorectal Cancer
NCT06675513 ·Status: SUSPENDED ·Phase: EARLY_PHASE1
-
Neoantigen-based Peptide Vaccine and Conventional Third-line Therapy for CRC Progressed After Second-line Treatment
NCT06751966 ·Status: RECRUITING ·Phase: NA
-
EGFR CART Cells for Patients With Metastatic Colorectal Cancer
NCT03152435 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
CART Therapy in Digestive System Tumors
NCT04780529 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Neoantigen-loaded DC Vaccine and Conventional Second-line Therapy for CRC Progressed After First-line Treatment
NCT06751940 ·Status: RECRUITING ·Phase: NA
-
Neoantigen-based Peptide Vaccine and Conventional Second-line Therapy for CRC Progressed After First-line Treatment
NCT06751914 ·Status: RECRUITING ·Phase: NA
-
Safety and Efficacy of CEA-Targeted CAR-T Therapy for Relapsed/Refractory CEA+ Cancer
NCT04348643 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
CEA-Targeted CAR-T Therapy in CEA-Positive Advanced Solid Tumors
NCT07179692 ·Status: RECRUITING ·Phase: PHASE1
-
EGFR-IL12-CART Cells for Patients With Metastatic Colorectal Cancer
NCT03542799 ·Status: UNKNOWN ·Phase: PHASE1
-
A Clinical Study of CEA-targeted CAR-T in the Treatment of CEA-positive Advanced Malignant Solid Tumors
NCT05396300 ·Status: RECRUITING ·Phase: PHASE1
-
Anti-PD-1 Antibody Combined With Autologous DC and NK Cells in the Treatment of Digestive Carcinoma
NCT05461235 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Safety and Efficiency of γδ T Cell Against Liver Cancer
NCT03183219 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Neoantigen-loaded DC Vaccine and Conventional Third-line Therapy for CRC Progressed After Second-line Treatment
NCT06751953 ·Status: RECRUITING ·Phase: NA
-
BGT007 Cells for the Treatment of Refractory Digestive System Tumors
NCT06104241 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Perioperative Chemotherapy VS Postoperative Chemotherapy for the Treatment of Colon Cancer With Resectable Liver Metastasis
NCT02912052 ·Status: UNKNOWN ·Phase: PHASE3
-
Radiofrquency Ablation Combined With Cytokine-induced Killer Cells for Colorectal Cancer Liver Metastases
NCT02419677 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Mix Vaccine for Metastatic Colorectal Cancer
NCT03357276 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Neoantigen Reactive T Cells c for Chinese Patients With Advanced Gastric Cancer
NCT06432075 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1