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Combining Cognitive Training With tDCS to Enhance Memory Inhibition in Young Binge Drinkers

NCT05237414 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 114

Last updated 2022-11-03

No results posted yet for this study

Summary

This study protocol aims to examine the behavioral and electroencephalographic (EEG) correlates of memory inhibition (MI) among college binge drinkers (BDs). A second objective is to evaluate an alcohol-specific MI training protocol using cognitive training (CT) and transcranial direct current stimulation (tDCS) while its effects on behavioral and EEG outcomes are assessed. Along with poor MI abilities, we hypothesized that BDs would show alterations in the amplitude of several event-related potentials (ERPs) linked to MI (e.g., N2 and late parietal positivity) as well as abnormal functional connectivity (FC) patterns within/between regions associated with MI (e.g., dorsolateral prefrontal cortex \[DLPFC\] and hippocampal/parahippocampal regions). Results should also demonstrate the effectiveness of the training protocol, with BDs exhibiting an improved capacity to suppress alcohol-related memories after both combined and cognitive MI training, along with a significant reduction in alcohol use and craving in the short/medium-term. Furthermore, this protocol should also lead to significant modifications in the ERP and FC patterns, reflecting stronger MI capabilities and reduced alcohol cue reactivity in trained BD participants.

Conditions

  • Binge Drinking

Interventions

DEVICE

Active tDCS

20 minutes of 2.0 mA direct current applied over the right DLPFC

DEVICE

Sham tDCS

15 seconds of 2.0 mA direct current applied over the right DLPFC

BEHAVIORAL

Active CT

Active memory inhibition CT (i.e., training of memory inhibition specifically for alcohol-related memories).

BEHAVIORAL

Sham CT

Sham memory inhibition CT (i.e., participants have to categorize alcoholic and non-alcoholic images but they do not have to inhibit the memories related to these images).

Sponsors & Collaborators

  • University of Minho

    lead OTHER

Principal Investigators

  • Eduardo G. López-Caneda, PhD · University of Minho

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
24 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-02-05
Primary Completion
2022-05-05
Completion
2022-08-15

Countries

  • Portugal

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05237414 on ClinicalTrials.gov