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A Randomized Trial of Imaging Selection Modalities for Stroke Thrombectomy (NO-SELECT)

NCT05230914 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1846

Last updated 2025-12-26

No results posted yet for this study

Summary

Several studies suggest that advanced multi-modal imaging with CTP should be used to screen late time window stroke patients for thrombectomy. However, NCCT is more accessible when comparing with CTP. It is unclear whether the NCCT-based ASPECTS can be used as an imaging criterion to screen patients for thrombectomy.

The newly published MR CLEAN-LATE and TENSION trials used NCCT or CTA, but still relied on ASPECTS scores to evaluate and select patients for endovascular therapy. However, different trials have different time windows. The aim of this trial was to assess the clinical outcomes of stroke patients with anterior large vessel occlusion who selected by simple imaging (NCCT) comparing via standard imaging screening strategy (CTP/MRI). The hypothesis is that simple imaging is non-inferior to standard imaging selection strategy in terms of achieving favorable outcomes.

Conditions

  • Stroke, Ischemic
  • Stroke, Acute

Interventions

OTHER

Simplified imaging strategy

NCCT and CTA will be used to screen patients for endovascular treatment

OTHER

Standard imaging strategy

NCCT-ASPECTS (pc-ASPECTS), CTA, and CTP will be used to screen patients for endovascular treatment

Sponsors & Collaborators

  • The First Affiliated Hospital of Hainan Medical University

    collaborator OTHER_GOV

  • Dalian Central Hospital

    collaborator UNKNOWN

  • Huai'an First People's Hospital

    collaborator OTHER

  • Xinqiao Hospital of Chongqing

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-12-12
Primary Completion
2027-06-30
Completion
2027-10-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05230914 on ClinicalTrials.gov