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Central Nervous System Effects Following Infusion of Diphenhydramine Using Pharmacokinetic and Pharmacodynamic Modeling

NCT05219604 · Status: TERMINATED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 3

Last updated 2026-01-22

Study results available
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Summary

This study seeks to explore the magnitude and duration of central nervous system effects and pharmacokinetics after intravenous infusion of diphenhydramine.

Conditions

  • Central Nervous System Effects of Diphenhydramine
  • Pharmacokinetics of Diphenhydramine

Interventions

DRUG

DiphenhydrAMINE Injectable Solution

Intravenous infusion of diphenhydramine 50 mg.

Sponsors & Collaborators

  • Dent Neuroscience Research Center

    lead OTHER

Principal Investigators

  • Michelle Rainka, PharmD · Dent Neurologic Institute

Study Design

Allocation
NA
Purpose
OTHER
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-03-15
Primary Completion
2022-10-04
Completion
2022-10-04
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05219604 on ClinicalTrials.gov