Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia

Summary

ACCURATE will test the hypothesis that opportunistic genetic testing for Familial Hypercholesterolemia (FH) in patients admitted to hospital with an acute coronary syndrome will increase the diagnosis of FH and will impact patient care and outcomes. The study will recruit patients admitted to hospital with an acute coronary syndrome, and research-based genetic testing will be conducted for known FH-causing genetic variants. The results will be returned to the patients' treating physicians. The primary endpoint will be the number of patients with a new diagnosis of definite FH. The secondary endpoints will be the proportion of patients who undergo intensification of lipid-lowering therapy, the lowest LDL cholesterol level achieved, and the proportion of patients reaching guideline recommended lipid targets in the 15 months after the index acute coronary syndrome.

Conditions

• Familial Hypercholesterolemia
• Familial Hypercholesterolemia Due to Genetic Defect of Apolipoprotein B
• Familial Hypercholesterolemia Due to Heterozygous LDL Receptor Mutation
• Familial Hypercholesterolemia - Heterozygous
• Acute Coronary Syndrome
• NSTEMI - Non-ST Segment Elevation MI
• STEMI
• Familial Hypercholesterolemia With Hyperlipemia

Interventions

DIAGNOSTIC_TEST

Research-based genetic test for Familial Hypercholesterolemia

Next-generation targeted sequencing assay to identify DNA variants in genes known to cause Familial Hypercholesterolemia

Sponsors & Collaborators

• Genome British Columbia

  collaborator INDUSTRY

• Vancouver Coastal Health Research Institute

  collaborator OTHER

• University of British Columbia

  lead OTHER

Principal Investigators

• Liam Brunham, MD PhD · University of British Columbia

Study Design

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Model

SEQUENTIAL

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-01-01

Primary Completion

2024-06-17

Completion

2025-08-29

Countries

• Canada

Study Locations