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Early Detection of Coronary Artery Disease by Polygenic and Metabolic Risk Scoring

NCT04604353 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1059

Last updated 2024-08-22

No results posted yet for this study

Summary

The overall goal of this study is to develop a combined polygenic risk score (PRS) and metabolic risk score (MRS) and determine its impact on selecting community members for CCS. The trial component of this study will compare the use of these scores to motivate people to adhere to therapy, an ongoing challenge for clinicians, by providing feedback in a meaningful form to both the clinicians and the patients.

Conditions

Interventions

DIAGNOSTIC_TEST

Polygenic Risk Score

Risk description to patient based on PRS

DIAGNOSTIC_TEST

Coronary Calcium Score

Risk description to patient based on CCS

Sponsors & Collaborators

  • Baker Heart and Diabetes Institute

    lead OTHER

Principal Investigators

  • Thomas H Marwick, MD, PhD, MPH · Baker Heart and Diabetes Institute

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-12-07
Primary Completion
2023-12-30
Completion
2023-12-30

Countries

  • Australia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04604353 on ClinicalTrials.gov