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Airway Closure During Extracorporeal Membrane Oxygenation: The AiCLOSE Study

NCT05196074 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 299

Last updated 2024-05-10

No results posted yet for this study

Summary

About 65,000 Canadians develop acute respiratory failure requiring breathing machines (ventilators) to give oxygen to their lungs. Unfortunately, up to 50% of these individuals will not survive their illness.

Mechanical ventilation through breathing machines, though potentially lifesaving, may further injure the lungs and the respiratory muscles. In the patients with the most severe and life threatening forms of respiratory failure a breathing machine alone may not be able to provide enough oxygen to the lungs and vital organs. In these critical situations, patients may require an artificial lung machine, which is referred to as extracorporeal membrane oxygenation (ECMO) to temporarily replace the function of the patient's own lung and supply critical oxygen to the body, while protecting the damaged lungs. How to use the breathing machine safely while a patient is on ECMO is still unknown. Using conventional breathing machine settings while on ECMO can lead to large portions of the lungs or airway to remain collapsed, which can contribute to further lung damage.

The investigators have recently discovered a way of detecting if patients on a breathing machine suffer from collapsed airways. Knowing if the most severe patients on ECMO have airway collapse is a pivotal question that the investigators plan to answer in our study. The investigators will use our technique to determine how many patients on ECMO have airway closure and determine if this contributes to a longer time on ECMO and a longer time on a breathing machine, and if this impacts a patient's survival in the intensive care unit.

Conditions

  • Acute Hypoxemic Respiratory Failure

Interventions

OTHER

Acute hypoxemic respiratory failure patients on VV-ECMO

To describe the prevalence of complete airway closure in patients with acute hypoxemic respiratory failure on VV-ECMO and its association with outcome.

Sponsors & Collaborators

  • Unity Health Toronto

    collaborator OTHER

  • Lorenzo delSorbo

    lead OTHER

Principal Investigators

  • Lorenzo Del Sorbo, MD · University Health Network, Toronto

  • Laurent Brochard, MD · Unity Health Toronto

  • Michael Sklar, MD · Unity Health Toronto

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-04-04
Primary Completion
2025-04-30
Completion
2026-04-30

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05196074 on ClinicalTrials.gov