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MuLtimodality EvaluatiOn of aNtibody mEdiated Damage in Heart Transplantation (LEONE-HT)

NCT05184426 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2022-06-21

No results posted yet for this study

Summary

Cross-sectional evaluation of antibody mediated injury in heart transplantation patients through a multimodal approach: electron microscopy, optic microscopy, immunohistochemistry techniques, transthoracic echocardiography, cardiac magnetic resonance, pressure guide wire, intravascular ultrasound

Conditions

  • Transplant Failure
  • Heart Transplant Rejection
  • Antibody-mediated Rejection

Interventions

DIAGNOSTIC_TEST

Echocardiogram

Ultrasound study to assess cardiac anatomy and function

DIAGNOSTIC_TEST

Cardiac magnetic resonance

MR to assess cardiac anatomy, function and tissue damage

DIAGNOSTIC_TEST

Coronary angiography

Cathteterization to assess coronary anatomy. Intravascular ultrasound to obtained a detailed assessment of vessels anatomy. Guidewire pressure to assess microcirculation

DIAGNOSTIC_TEST

Endomyocardial biopsy

Optic microscopy, immunofluorescence, transmission electron microscopy

Sponsors & Collaborators

  • Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III

    collaborator OTHER

  • Juan Francisco Delgado Jimenez

    lead OTHER

Principal Investigators

  • Juan F Delgado, MD PhD · University Hospital 12 de Octubre

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-04-01
Primary Completion
2024-09-30
Completion
2029-09-30

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05184426 on ClinicalTrials.gov